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ICG-001

CAT: 0400-SIH-387-5MGSize: 5 mgDry Ice: NoHazardous: No
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CAT#:0400-SIH-387-5MGSize:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Inhibitor of TCF/β-catenin-mediated transcription. Selectively inhibits β-catenin/CBP interaction; displays no effect on β-catenin/p300 interaction. Exhibits growth inhibitory effects in colon carcinoma cell lines (SW480 and HCT-116 cells); also displays efficacy in Min mouse and nude mouse SW620 xenograft models.
Description
β-catenin inhibitor
CAS Number
847591-62-2
Product Name Alternative
(6S,9aS) -Hexahydro-6-[ (4-hydroxyphe­nyl) methyl]-8- (1-naphthalenylmethyl) -4,7-dioxo-N- (­phenylmethyl) -2H-pyrazino[1,2-a]pyrimidine-1 (6H) -c­arboxamide
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling
Purity
>98%
Weight
0.005
Format
White solid
Solubility
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Molecular Formula
C33H32N4O4
Molecular Weight
548.63
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Emami K.H., et al. (2004) Proc. Natl. Acad. Sci. USA. 101(34): 12682-7. 2. De Sousa E.M., et al. (2011) Clin. Cancer Res. 17(4): 647-53. 3. Zhou B., et al. (2012) J. Biol. Chem. 287(10): 7026-38.

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