ICG-001

• Background:

  Inhibitor of TCF/β-catenin-mediated transcription. Selectively inhibits β-catenin/CBP interaction; displays no effect on β-catenin/p300 interaction. Exhibits growth inhibitory effects in colon carcinoma cell lines (SW480 and HCT-116 cells); also displays efficacy in Min mouse and nude mouse SW620 xenograft models.

• Description:

  β-catenin inhibitor

• Product Name Alternative:

  (6S,9aS) -Hexahydro-6-[ (4-hydroxyphe­nyl) methyl]-8- (1-naphthalenylmethyl) -4,7-dioxo-N- (­phenylmethyl) -2H-pyrazino[1,2-a]pyrimidine-1 (6H) -c­arboxamide

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cell Signaling

• Purity:

  >98%

• Weight:

  0.025

• Format:

  White solid

• Solubility:

  Soluble to 100 mM in DMSO and to 50 mM in ethanol

• Molecular Formula:

  C33H32N4O4

• Molecular Weight:

  548.63

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Emami K.H., et al. (2004) Proc. Natl. Acad. Sci. USA. 101(34): 12682-7. 2. De Sousa E.M., et al. (2011) Clin. Cancer Res. 17(4): 647-53. 3. Zhou B., et al. (2012) J. Biol. Chem. 287(10): 7026-38.

• CAS Number:

  847591-62-2