SP600125

• Background:

  Selective inhibitor of c-Jun N-terminal kinase (JNK). Competitively and reversibly inhibits JNK1, 2 and 3 (IC50 = 40 - 90 nM) with negligible activity at ERK2, p38β and a range of enzymes (IC50 > 10 µM). Active in vivo. Shown to have reduced selectivity over other protein kinases under certain conditions. Protects renal tubular epithelial cells against ischemia/reperfusion-induced apoptosis.

• Description:

  Jnk inhibitor

• Product Name Alternative:

  Anthra (1,9-cd) pyrazol-6 (2H) -one, 1,9-Pyrazoloanthrone

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cell Signaling | Cancer | Apoptosis

• Purity:

  >98%

• Weight:

  0.05

• Format:

  Yellow to brown solid

• Solubility:

  Soluble in DMSO or methanol

• Molecular Formula:

  C14H8N2O

• Molecular Weight:

  220.2

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Bennett B.L., et al. (2001) Proc. Natl. Acad. Sci. U.S.A. 98(24): 13681-6. 2. Schnabl B., et al. (2001) Hepatology. 34(5): 953-63. 3. Bain J., et al. (2003) Biochem. J. 371(Pt 1): 199-204. 4. Wang Y., et al. (2007) Life Sci. 80(22): 2067-75.

• CAS Number:

  129-56-6