IOX1

• Background :

  IOX1 is a cell permeable inhibitor of the JMJD family of 2-oxoglutarate-dependent histone demethylases (IC50 = 0.12, 0.07, 0.2, 0.3, 0.6, and 1 M for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively1). It is a broad spectrum 2-oxoglutarate oxygenase inhibitor which may be used to study hypoxic signaling (1).

• Description :

  JMJD inhibitor

• CAS Number :

  5852-78-8

• Product Name Alternative :

  8-Hydroxy-5-quinolinecarboxylic acid; (5-Carboxy-8HQ)

• UNSPSC :

  41116105

• Type :

  Inhibitor

• Source :

  Synthetic

• Field of Research :

  Cell Signaling | Epigenetics and Nuclear Signaling

• Purity :

  ≥98% (TLC) ; NMR (Conforms)

• Weight :

  0.025

• Format :

  Yellow powder

• Solubility :

  May be dissolved in DMSO (20 mg/ml)

• Molecular Formula :

  C10H7NO3

• Molecular Weight :

  189.2

• Precautions :

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations :

  1. King O.N., et al. (2010) PLoS One. 5: e15535.