Fasudil

• Background:

  Fasudil is a ROCK2 inhibitor with some action on PRK2 and MSK1 (IC50 values are 1.9 µM, 4 µM and 5 µM respectively). It is also shown to inhibit RSK1, RSK2, PKA, AMPK and PKd1. It is also a calcium channel antagonist and vasodilator.

• Description:

  ROCK inhibitor

• Product Name Alternative:

  1- (5-Isoquinolinylsulfonyl) homopiperazine hydrochloride; 5- (1,4-Diazepan-1-ylsulfonyl) isoquinoline

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cell Signaling | Neuroscience | Neurodegeneration | Parkinson's Disease | Synuclein

• Purity:

  ≥98% (TLC) ; NMR (Conforms)

• Weight:

  0.05

• Format:

  Powder

• Solubility:

  May be dissolved in DMSO (75 mg/ml) or water (100 mg/ml)

• Molecular Formula:

  C14H17N3O2S•HCl

• Molecular Weight:

  327.83

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Shirotani M., et al. (1991) J. Pharmacol. Exp. Ther. 259(2): 738-744. 2. Arai M., Nozawa R., et al. (1993) Biochem. Pharmacol. 46(8): 1487-1490. 3. Satoh S., et al. (1996) Br. J. Pharmacol. 118(7): 1592-1606. 4. Sward K., et al. (2000) J. Physiol. 522: 33-49.

• CAS Number:

  103745-39-7