Xanthohumol

• Background:

  Xanthohumol is a valosin-containing protein (VCP) inhibitor which binds to the N-domain of VCP, suppressing function and impairing autophagosome maturation (1). It also inhibits growth of a wide variety of human cancer cell lines by inhibiting proliferation and inducing apoptosis (2).

• Description:

  Autophagy inhibitor

• Product Name Alternative:

  (2E) -1-[2,4-Dihydroxy-6-methoxy-3- (¬3-methyl-2-buten-1-yl) phenyl]-3- (4-hydroxyphenyl) -¬2-propen-1-one

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cancer | Autophagy

• Purity:

  ≥98% (TLC) ; NMR (Conforms)

• Weight:

  0.05

• Format:

  Yellow solid

• Solubility:

  May be dissolved in DMSO (35 mg/ml) or Ethanol (35 mg/ml)

• Molecular Formula:

  C21H22O5

• Molecular Weight:

  354.4

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Sasazawa Y., et al. (2012) ACS Chem Biol. 7(5): 892-900. 2. Vene R., et al. (2012) Mol. Med. 18: 1292.

• CAS Number:

  6754-58-1