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Leflunomide

CAT: 0400-SIH-368-50MGSize: 50 mgDry Ice: NoHazardous: No
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CAT#:0400-SIH-368-50MGSize:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Leflunomide is an Immuno-suppressant, it inhibits de novo synthesis of pyrimidine nucleotides and the activity of the protein kinase. It is a part of the known “disease-modifying anti-rheumatic drugs” (DMARD). It has been suggested that leflunomide modulates the expansion of activated autoimmune lymphocytes acting on the regression of rheumatoid conditions (1-2). It has been shown to have a double mechanism of action by slowing down and relieving the pain of rheumatoid arthritis. Studies have shown the lethal effects of Leflunomide after administration to mice in various doses (3).
Description
Immunosupressant
CAS Number
75706-12-6
Product Name Alternative
5-methyl-N-[4- (trifluoromethyl) phenyl]-isoxazole-4-carboxamide
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Neuroscience
Purity
>98% (TLC: 5:95, CH3OH/CH2Cl2; Rf=0.65) ; NMR (Conforms)
Weight
0.05
Format
White crystalline solid
Solubility
May be dissolved in DMSO (30 mg/ml); or Ethanol (27 mg/ml)
Molecular Formula
C12H9F3N2O2
Molecular Weight
270.21
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Fukushima R., Kanamori S., Hirashiba M., et al. (2007) Reprod. Toxical. 24(3-4): 310-316. 2. Smolen JS., Emery P. (2000) Rheumatology. 39: 48-56. 3. Fox R.I., Herrman M.L., Franqou C.G., Wahl G.M., Morns R.E., Strand V. and Kirschbaum B.S. (1999) Clin Immunol 93(3): 198-208.

Alternative Products

CatalogName
255673Leflunomide

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