PJ-34

• Background:

  PJ-34 is a selective inhibitor of Poly (ADP-Ribose) polymerase (PARP). Studies have shown that the use of PJ-34 on severe inflammatory diseases, in particular experimental allergic encephalomyelitis (EAE) have contributed to a shift of the immune response from a pro-inflammatory Th1 to anti-inflammatory th2 phenotype (1).

• Description:

  PARP inhibitor

• Product Name Alternative:

  N- (6-Oxo-5,6-dihydrophenanthridin-2-yl) -N, Ndimethylacetamide . HCl

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cancer | Apoptosis | Cancer Growth Inhibitors | PARP Inhibitors

• Purity:

  ≥98% (HPLC) ; NMR (Conforms)

• Weight:

  0.05

• Format:

  White to yellow solid.

• Solubility:

  May be dissolved in DMSO (30 mg/ml) or water (20 mg/ml)

• Molecular Formula:

  C17H17N3O2•HCL•H2O

• Molecular Weight:

  331.8

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Scott G., Kean R., Mikheeva., Fabis M., Mabley J.J. (2004) The Journal of Pharmacology and Exp. Therapeutics. 310(3): 1053-1061.

• CAS Number:

  344458-15-7