Carnosic acid

• Background:

  Carnosic acid is a benzenediol abietane diterpene naturally extracted from rosemary (Rosmarinus officinalis) and sage (Saliva officinalis). It is a potent antioxidant that inhibits NADH or NADPH induced lipid peroxidation by acting as a free radical scavenger (1). It has been found to increase cellular levels of glutathione (GSH) and prevent 6-hydroxydopamine-induced cell death in SH-SY5Y cells (2). Carnosic acid-stimulation of GSH also inhibits adipocyte differentiation (3). It has also been found to induce apoptosis (4) and inhibit the proliferation and migration of various tumor cell lines (5).

• Description:

  PPARγ activator

• Product Name Alternative:

  (4aR,10aS) -5,6-Dihydroxy-7-isopropyl-1,1-dimethyl-1,3,4,9,10,10a-hexahydro-2H-phenanthrene-4a-carboxylic acid

• UNSPSC:

  41116105

• Type:

  Activator

• Source:

  Synthetic

• Field of Research:

  Cancer | Apoptosis

• Purity:

  ≥95% (HPLC) ; NMR (Conforms)

• Weight:

  0.01

• Format:

  Off white to yellow solid

• Solubility:

  Soluble in DMSO (50 mg/ml)

• Molecular Formula:

  C20H28O4

• Molecular Weight:

  332.43

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Schwarz K., Ternes W. (1992) Zeitschrift für Lebensmittel-Untersuchung und –Forschung. 195 (2): 99-103. 2. Chen J.H., et al. Chem. (2012) Res. Toxicol 25:1893. 3. Takahashi T., et al. (2009) Biochem. Biophys. Res. Commun. 382:549. 4. Kar S., et al. (2012) Apoptosis. 17:1735. 5. Barni M.V., et al. (2012) Oncol. Rep. 27:1041.

• CAS Number:

  3650-09-7