Sodium Valproate

• Background:

  Histone deacetylase inhibitor (IC50=400 µM). Demonstrates neuroprotective, anticancer and anti-inflammatory activity. Inhibits Aβ production and neuritic plaque formation in Alzheimer's mouse models. Clinically useful anticonvulsant.

• Description:

  HDAC inhibitor

• Product Name Alternative:

  2-Propylpentanoic acid Na

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cell Signaling | Epigenetics and Nuclear Signaling | Cancer

• Purity:

  >98% (TLC), NMR conforms

• Weight:

  5

• Format:

  White Solid

• Solubility:

  Soluble in 50 mg/ml Water

• Molecular Formula:

  C8H15NaO2

• Molecular Weight:

  166.2

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Phiel C.J., et al. (2001) J. Biol. Chem. 276: 36734. 2. Kim H.J., et al. (2007) J. Pharmacol. Exp. Ther. 321: 892. 3. Qing H., et al. (2008) J. Exp. Med. 205: 2781.

• CAS Number:

  1069-66-5