EX-527

• Background:

  Selective SIRT1 inhibitor (IC50=98 nM). Does not inhibit other HDACs or SIRT family members. Increases p53 acetylation following DNA damage. Cell permeable.

• Description:

  SIRT1 inhibitor

• Product Name Alternative:

  6-Chloro-2,3,4,9-tetrahydro-1Hcarbazole-1-carboxamide (racemic)

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cell Signaling | Epigenetics and Nuclear Signaling

• Purity:

  >98% (TLC), NMR conforms

• Weight:

  0.025

• Format:

  Light Yellow Solid

• Solubility:

  Soluble in 18 mg/ml DMSO or 10 mg/ml Ethanol

• Molecular Formula:

  C13H13ClN2O

• Molecular Weight:

  248.7

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Solomon J.M., et al., (2006) Mol. Cell. Biol. 26: 28. 2. Anderson J.L., et al., (2011) Mol.Cell 43: 834.

• CAS Number:

  49843-98-3