Decitabine

• Background :

  Inhibits DNA methyltransferase. Induces demethylation and reactivation of silenced genes. Increases stem cell reprogramming efficiency. Stimulates osteogenic differentiation of human bone marrow stromal cells. Antitumor agent. Cell permeable.

• Description :

  DNA hypomethylation agent

• Product Name Alternative :

  5-Aza-2'-deoxycytidine; NSC-127716, 2'-Deoxy-5-azacytidine; 4-Amino-1- (2-deoxy-β-D-erythro-pento furanosyl) -1,3,5-triazin-2 (1H) -one

• UNSPSC :

  41116105

• Type :

  Inhibitor

• Source :

  Synthetic

• Field of Research :

  Cell Signaling | Epigenetics and Nuclear Signaling | Cancer

• Purity :

  >98% (TLC), NMR conforms

• Weight :

  0.05

• Format :

  White Solid

• Solubility :

  Soluble in 25 mg/ml DMSO, 11 mg/ml Water or Ethanol

• Molecular Formula :

  C8H12N4O4

• Molecular Weight :

  228.2

• Precautions :

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations :

  1. Bender C.M., et al. (1998) Cancer Res. 58: 95. 2. El-Serafi A.T., et al. (2011) Differentiation 81: 35.

• CAS Number :

  2353-33-5