BIX-01294

• Background:

  G9a-like protein and G9a histone lysine methyltransferase inhibitor (IC values are 0.7 and 1.7 µM respectively) that displays no activity at other histone methyltransferases up to 37 µM. Modulates H3K9me2 levels in mammalian cells and potentiates induction of pluripotent stem cells from somatic cells in vitro.

• Description:

  HMT inhibitor

• Product Name Alternative:

  2- (Hexahydro-4-methyl-1H-1,4-diazepin-1-yl) -6,7-dimethoxy-N-[1- (phenylmethyl) -4-piperidinyl]-4-quinazolinamine trihydrochloride; N- (1-Benzyl-4-piperidinyl) -6,7-dimethoxy-2- (4-methyl-1,4-diazepan-1-yl) -4-quinazolinamine trihydrochloride

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cell Signaling | Epigenetics and Nuclear Signaling | Cancer

• Purity:

  >98%

• Weight:

  0.025

• Format:

  Cream solid

• Solubility:

  May be dissolved in DMSO (100 mM) or Water (100 mM)

• Molecular Formula:

  C28H38N6O2*3HCl

• Molecular Weight:

  600.02

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Kubicek S., et al. (2007) Mol Cell. 25(3): 473-481. 2. Shi Y., et al. (2008) Cell Stem Cell. 3(5): 568-574. 3. Chang Y., et al. (2009) Nat Struct Mol Biol. 16(3): 312-317.

• CAS Number:

  935693-62-2