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NSC-66811

CAT: 0400-SIH-338-50MGSize: 50 mgDry Ice: NoHazardous: No
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CAT#:0400-SIH-338-50MGSize:50 mg
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Background
A novel inhibitor of the MDM2-p53 interaction. Mimics three p53 residues involved in binding to MDM2. Binds to MDM2 with a Ki of 120 nM. Activates p53 in cancer cells. Cell permeable.
Description
P53/mdm2 inhibitor
CAS Number
6964-62-1
Product Name Alternative
2-Methyl-7-[Phenyl (phenylamino) meth­yl]-8-quinolinol, 7-[Anilino (phenyl) methyl]-2-methylquinolin-8-ol
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Apoptosis | Cancer Growth Inhibitors | p53/mdm2 Inhibitors
Purity
>98%
Weight
0.05
Format
White Solid
Solubility
Soluble in 25 mg/ml DMSO
Molecular Formula
C23H20N2O
Molecular Weight
340.4
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Lu Y., et al. (2006) J. Med.Chem. 49: 3759.

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