NSC-66811

• Background :

  A novel inhibitor of the MDM2-p53 interaction. Mimics three p53 residues involved in binding to MDM2. Binds to MDM2 with a Ki of 120 nM. Activates p53 in cancer cells. Cell permeable.

• Description :

  P53/mdm2 inhibitor

• Product Name Alternative :

  2-Methyl-7-[Phenyl (phenylamino) meth­yl]-8-quinolinol, 7-[Anilino (phenyl) methyl]-2-methylquinolin-8-ol

• UNSPSC :

  41116105

• Type :

  Inhibitor

• Source :

  Synthetic

• Field of Research :

  Cancer | Apoptosis | Cancer Growth Inhibitors | p53/mdm2 Inhibitors

• Purity :

  >98%

• Weight :

  0.01

• Format :

  White Solid

• Solubility :

  Soluble in 25 mg/ml DMSO

• Molecular Formula :

  C23H20N2O

• Molecular Weight :

  340.4

• Precautions :

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations :

  1. Lu Y., et al. (2006) J. Med.Chem. 49: 3759.

• CAS Number :

  6964-62-1