Thalidomide

CAT: 0400-SIH-336-500MGSize: 500 mgDry Ice: NoHazardous: No
CAT#:0400-SIH-336-500MGSize:500 mg
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Background
Binds to the E3 ubiquitin ligase complex formed between CRBN, DDB1 and Cul4A inhibiting ligase activity. Inhibits TNF synthesis and FGF-induced angiogenesis. Cell permeable. Caution: Teratogenic.
Description
E3 UB ligase inhibitor
CAS Number
50-35-1
Product Name Alternative
(±) -2- (2,6-Dioxo-3-piperidinyl) -1H-isoindole-1,3 (2H) -dione, N- (2,6-dioxo-3-piperidinyl) phthalim­ide
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Apoptosis
Purity
>98%
Weight
0.5
Format
White Solid
Solubility
Soluble in 5 mg/ml DMSO
Molecular Formula
C13H10N2O4
Molecular Weight
258.2
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Ito T., et al. (2010) Science. 327:1345. 2. Weglicki W.B., et al. (1993) Mol. Cell. Biochem. 129:195. 3. D'Amato R.J., et al. (1994) Proc. Natl. Acad. Sci. USA. 91:4082.

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