Thalidomide

• Background:

  Binds to the E3 ubiquitin ligase complex formed between CRBN, DDB1 and Cul4A inhibiting ligase activity. Inhibits TNF synthesis and FGF-induced angiogenesis. Cell permeable. Caution: Teratogenic.

• Description:

  E3 UB ligase inhibitor

• Product Name Alternative:

  (±) -2- (2,6-Dioxo-3-piperidinyl) -1H-isoindole-1,3 (2H) -dione, N- (2,6-dioxo-3-piperidinyl) phthalim­ide

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cancer | Apoptosis

• Purity:

  >98%

• Weight:

  0.5

• Format:

  White Solid

• Solubility:

  Soluble in 5 mg/ml DMSO

• Molecular Formula:

  C13H10N2O4

• Molecular Weight:

  258.2

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Ito T., et al. (2010) Science. 327:1345. 2. Weglicki W.B., et al. (1993) Mol. Cell. Biochem. 129:195. 3. D'Amato R.J., et al. (1994) Proc. Natl. Acad. Sci. USA. 91:4082.

• CAS Number:

  50-35-1