LDN-57444

• Background:

  Inhibits ubiquitin C-terminal hydrolase (UCH-L1) (Ki=0.4 M). Decreases proteasome activity and increases levels of ubiquitinated proteins. Induces apoptosis. Causes dramatic alterations in synaptic protein distribution and spine morphology in vivo. Cell permeable.

• Description:

  DUB inhibitor

• Product Name Alternative:

  3- (O-acetyloxime), 5-chloro-1-[ (2,5-dichlorophenyl) methyl]-1H-Indole-2,3-dione, C30, LDN 57444

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cancer | Apoptosis

• Purity:

  >98%

• Weight:

  0.05

• Format:

  Yellow Powder

• Solubility:

  Soluble in 20 mg/ml DMSO

• Molecular Formula:

  C17H11Cl3N2O3

• Molecular Weight:

  397.6

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Liu Y., et al. (2003) Chem. Biol. 10: 837. 2. Tan Y.Y., et al. (2008) Mol. Cell. Biochem. 318: 109. 3. Cartier A.E., et al. (2009) J.Neurosci. 29: 7857.

• CAS Number:

  668467-91-2