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LDN-57444

CAT: 0400-SIH-332-10MGSize: 10 mgDry Ice: NoHazardous: No
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CAT#:0400-SIH-332-10MGSize:10 mg
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Background
Inhibits ubiquitin C-terminal hydrolase (UCH-L1) (Ki=0.4 M). Decreases proteasome activity and increases levels of ubiquitinated proteins. Induces apoptosis. Causes dramatic alterations in synaptic protein distribution and spine morphology in vivo. Cell permeable.
Description
DUB inhibitor
CAS Number
668467-91-2
Product Name Alternative
3- (O-acetyloxime), 5-chloro-1-[ (2,5-dichlorophenyl) methyl]-1H-Indole-2,3-dione, C30, LDN 57444
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Apoptosis
Purity
>98%
Weight
0.01
Format
Yellow Powder
Solubility
Soluble in 20 mg/ml DMSO
Molecular Formula
C17H11Cl3N2O3
Molecular Weight
397.6
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Liu Y., et al. (2003) Chem. Biol. 10: 837. 2. Tan Y.Y., et al. (2008) Mol. Cell. Biochem. 318: 109. 3. Cartier A.E., et al. (2009) J.Neurosci. 29: 7857.

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