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Bortezomib

CAT: 0400-SIH-328-5MGSize: 5 mgDry Ice: NoHazardous: No
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CAT#:0400-SIH-328-5MGSize:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Potent and selective proteasome inhibitor (Ki=0.6 nM). Inhibits proliferation of a number of tumor cell lines (IC50=7 nM). Inhibits TNF synthesis and FGF-induced angiogenesis. Reversible. Cell permeable.
Description
Proteasome inhibitor
CAS Number
179324-69-7
Product Name Alternative
B-[ (1R) -3-Methyl-1-[[ (2S) -1-oxo-3-phenyl-2-[ (2-pyrazinylcarbonyl) amino]propyl]amino]butyl]boronic Acid; [ (1R) -3-Methyl-1-[[ (2S) -1-oxo-3-phenyl-2-[ (pyrazinylcarbonyl) amino]propyl]amino]butyl]boronic Acid; Velcade; Radiciol; NSC 681239; DPBA; LDP 341; MG 341; mlN 341; NSC 681239; PS 314; PS 341; Radiciol; Velcade
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Apoptosis | Cancer Growth Inhibitors | Proteasome Inhibitors
Purity
>98%
Weight
0.005
Format
White Powder
Solubility
Soluble in 50 mg/ml DMSO, 35 mg/ml Ethanol
Molecular Formula
C19H25BN4O4
Molecular Weight
384.2
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Adams J., et al. (1999) Cancer Res. 59: 2615. 2. Williams S., et al. (2003) Mol. Cancer Ther. 2: 835.

Alternative Products

CatalogName
RM-B201439-01Bortezomib

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