Lactacystin

• Background:

  Specific inhibitor of three proteolytic activities of the proteasome. Chymotrypsin-like activity is inhibited most potently followed by trypsin-like activity. Peptidyl-glutamyl peptide hydrolytic activity is relatively weak.

• Description:

  Proteasome inhibitor

• Product Name Alternative:

  (2R,3S,4R) -3-Hydroxy-2-[ (1S) -1-hydroxy-2-methylpropyl]-4-methyl-5-oxo-2-pyrrolidinecarboxy-N-acetyl-L-cysteine thioester

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cancer | Apoptosis | Cancer Growth Inhibitors | Proteasome Inhibitors

• Purity:

  >98%

• Weight:

  0.0002

• Format:

  White Solid

• Solubility:

  Soluble in DMSO, Water or Ethanol

• Molecular Formula:

  C15H24N2O7S

• Molecular Weight:

  376.4

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Omura S., et al. (1991) J. Antibiot. 44: 113. 2. Fenteany G., et al. (1995) Science 268: 726

• CAS Number:

  133343-34-7