MG-132

• Background:

  Specific inhibitor of the 20S proteasome (Ki=4 nM). Blocks NFKB activation by blocking IKB proteolysis (IC50=3 M). It stimulates autophagy, induces heat shock response and is cell permeable

• Description:

  Proteasome Inhibitor

• Product Name Alternative:

  N-[ (Benzyloxy) carbonyl]-L-leucyl-N-[ (2S) -4-methyl-1-oxo-2-pentanyl]-L-leucinamide, Z-Leu-Leu-Leu-al, Z-LLL-CHO, N-​[ (phenylmethoxy) carbonyl]-​L-​leucyl-​N-​[ (1S) -​1-​formyl-​3-​methylbutyl]-​L-​leucinamide

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cancer | Heat Shock

• Purity:

  >98%

• Weight:

  0.005

• Format:

  White solid

• Solubility:

  Soluble in 45 mg/ml DMSO, DMF and ethanol

• Molecular Formula:

  C26H41N3O5

• Molecular Weight:

  475.6

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Tsubuki S., et al. (1996) J. Biochem. 119:572. 2. Wu W.K., et al. (2010) Autophagy 6:228. 3. Meriin A.B., et al. (1998) J. Biol. Chem. 273:6373.

• CAS Number:

  133407-82-6