MG-132

• Background :

  Specific inhibitor of the 20S proteasome (Ki=4 nM). Blocks NFKB activation by blocking IKB proteolysis (IC50=3 M). It stimulates autophagy, induces heat shock response and is cell permeable

• Description :

  Proteasome Inhibitor

• Product Name Alternative :

  N-[ (Benzyloxy) carbonyl]-L-leucyl-N-[ (2S) -4-methyl-1-oxo-2-pentanyl]-L-leucinamide, Z-Leu-Leu-Leu-al, Z-LLL-CHO, N-​[ (phenylmethoxy) carbonyl]-​L-​leucyl-​N-​[ (1S) -​1-​formyl-​3-​methylbutyl]-​L-​leucinamide

• UNSPSC :

  41116105

• Type :

  Inhibitor

• Source :

  Synthetic

• Field of Research :

  Cancer | Heat Shock

• Purity :

  >98%

• Weight :

  0.025

• Format :

  White solid

• Solubility :

  Soluble in 45 mg/ml DMSO, DMF and ethanol

• Molecular Formula :

  C26H41N3O5

• Molecular Weight :

  475.6

• Precautions :

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations :

  1. Tsubuki S., et al. (1996) J. Biochem. 119:572. 2. Wu W.K., et al. (2010) Autophagy 6:228. 3. Meriin A.B., et al. (1998) J. Biol. Chem. 273:6373.

• CAS Number :

  133407-82-6