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MG-132

CAT: 0400-SIH-326-25MGSize: 25 mgDry Ice: NoHazardous: No
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CAT#:0400-SIH-326-25MGSize:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Specific inhibitor of the 20S proteasome (Ki=4 nM). Blocks NFKB activation by blocking IKB proteolysis (IC50=3 M). It stimulates autophagy, induces heat shock response and is cell permeable
Description
Proteasome Inhibitor
CAS Number
133407-82-6
Product Name Alternative
N-[ (Benzyloxy) carbonyl]-L-leucyl-N-[ (2S) -4-methyl-1-oxo-2-pentanyl]-L-leucinamide, Z-Leu-Leu-Leu-al, Z-LLL-CHO, N-​[ (phenylmethoxy) carbonyl]-​L-​leucyl-​N-​[ (1S) -​1-​formyl-​3-​methylbutyl]-​L-​leucinamide
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Heat Shock
Purity
>98%
Weight
0.025
Format
White solid
Solubility
Soluble in 45 mg/ml DMSO, DMF and ethanol
Molecular Formula
C26H41N3O5
Molecular Weight
475.6
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Tsubuki S., et al. (1996) J. Biochem. 119:572. 2. Wu W.K., et al. (2010) Autophagy 6:228. 3. Meriin A.B., et al. (1998) J. Biol. Chem. 273:6373.

Alternative Products

CatalogName
A2585-SMG-132
1748/5MG 132

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