Pifithrin mu

• Background:

  Selectively interacts with HSP70 and disrupts its association with co-chaperones and substrate proteins. It induces apoptosis and is cell permeable. Also, inhibits p53 binding to mitochondria by reducing its affinity for antiapoptotic proteins Bcl-2 and Bcl-XL. Looking for more information on HSP70? Visit our new HSP70 Scientific Resource Guide at http://www.HSP70.com.

• Description:

  Hsp70 inhibitor

• Product Name Alternative:

  2-Phenylethynesulfonamide, PFTµ

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cancer | Heat Shock

• Purity:

  >98%

• Weight:

  0.01

• Format:

  White to off-white solid

• Solubility:

  Soluble in ethanol (110 mM) and in DMSO (110 mM)

• Molecular Formula:

  C8H7NO2S

• Molecular Weight:

  181.2

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Leu J.L., et al. (2009) Mol. Cell. 36: 15.

• CAS Number:

  64984-31-2