Felodipine

CAT: 0400-SIH-323-50MGSize: 50 mgDry Ice: NoHazardous: No
CAT#:0400-SIH-323-50MGSize:50 mg
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Background
Felodipine is an L-type Ca2+ channel blocker (1). In isolated rat ventricular myocytes, using a whole-cell patch-clamp technique, it displays a Ki of 11 nM (2). It is a clinically useful antihypertensive agent (3) which attenuates the hypertrophic effect of cyclosporine on transplanted hearts (4).
Description
L-type Ca channel blocker
CAS Number
72509-76-3
Product Name Alternative
Ethyl methyl 4- (2,3-dichlorophenyl) -2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate, Plendil
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Neuroscience | Ion Channels | Calcium Channels | Voltage-Gated Calcium Channels
Purity
>98% (TLC) ; NMR (Conforms)
Weight
0.05
Format
Light Yellow Solid
Solubility
Soluble to 100 mM in ethanol and to 100 mM in DMSO
Molecular Formula
C18H19Cl2NO4
Molecular Weight
384.25
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Furakawa T., et al. (2005) J Cardiovasc. Pharmacol. 45(3): 241-246. 2. Zahradnikova Z., Minarovic I., Zahradnik I. (2007) J Pharmacol Exp. Ther. 322(2): 638-645. 3. Manzo B.A., Matalka M.S., Ravnan S.L. (2003) Pharmacotherapy. 23(11): 1508-1512. 4. Schwitter J., et al. (1999) J Heart Lung Transplant. 18(10): 1003-1013.

Alternative Products

CatalogName
MBS3605774-01Felodipine

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