Felodipine

• Background:

  Felodipine is an L-type Ca2+ channel blocker (1). In isolated rat ventricular myocytes, using a whole-cell patch-clamp technique, it displays a Ki of 11 nM (2). It is a clinically useful antihypertensive agent (3) which attenuates the hypertrophic effect of cyclosporine on transplanted hearts (4).

• Description:

  L-type Ca channel blocker

• Product Name Alternative:

  Ethyl methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate, Plendil

• UNSPSC:

  41116105

• Source:

  Synthetic

• Purity:

  >98% (TLC); NMR (Conforms)

• Weight:

  0.01

• Format:

  Light Yellow Solid

• Solubility:

  Soluble to 100 mM in ethanol and to 100 mM in DMSO

• Molecular Formula:

  C18H19Cl2NO4

• Molecular Weight:

  384.25

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Furakawa T., et al. (2005) J Cardiovasc. Pharmacol. 45(3): 241-246. 2. Zahradnikova Z., Minarovic I., Zahradnik I. (2007) J Pharmacol Exp. Ther. 322(2): 638-645. 3. Manzo B.A., Matalka M.S., Ravnan S.L. (2003) Pharmacotherapy. 23(11): 1508-1512. 4. Schwitter J., et al. (1999) J Heart Lung Transplant. 18(10): 1003-1013.

• CAS Number:

  72509-76-3