Capsaicin

• Background :

  Capsaicin is an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel (1, 2). It exhibits neuroprotective effects in a model of transient global cerebral ischemia and induces release of substance P from afferent nociceptive specific neurons (1). Powerful excitant of peripheral sensory nerve endings, specifically unmyelinated afferent neurons (C-fibers). Reversibly inhibits aggregation of platelets (3).

• Description :

  TRPV1opener

• Product Name Alternative :

  (6E) -N- (4-Hydroxy-3-methoxybenzyl) -8-methyl-6-nonenamide, 8-Methyl-N-vanillyl-trans-6-nonenamide

• UNSPSC :

  41116105

• Type :

  Small Molecules

• Source :

  Synthetic

• Field of Research :

  Neuroscience | Ion Channels | Transient Receptor Potential (TRP) Channels

• Purity :

  >60% (HPLC) ; NMR (conforms)

• Weight :

  1

• Format :

  Off-White Solid

• Solubility :

  Soluble in DMSO (20 mg/mL) and ethanol (15 mg/mL)

• Molecular Formula :

  C18H27NO3

• Molecular Weight :

  305.41

• Precautions :

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations :

  1. Caterina M.J., et al. (1997) Nature. 389(6653): 816-824. 2. Story G.M., Crus-Orengo L. (2007) Am Scientist. 95(4): 326-333. 3. Vaishnava P., Wang D.H. (2003) Curr Med Chem Cadiovasc Hematol Agents. 1(2): 177-188.

• CAS Number :

  404-86-4