E-4031

• Background:

  E-4031 acts on a specific class of voltage gated potassium channels, the hERG channels. It does this by binding to the open channels, although its structural target is unclear (1-4). It is also an anti-arrhythmic drug (5).

• Description:

  Herg channel blocker

• Product Name Alternative:

  N-[4-[[1-[2- (6-Methyl-2-pyridinyl) ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride, dihydrate

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Neuroscience | Ion Channels

• Purity:

  >98% (TLC: CH2Cl2/CH3OH; 9:1 with 1% NH4OH; Silica gel 60; Rf=0.39) ; NMR conforms

• Weight:

  0.01

• Format:

  White solid

• Solubility:

  Soluble in water (100 mg/ml) and warm DMSO (25 mg/ml)

• Molecular Formula:

  C₂₁H₂₇N₃O₃S · 2HCl · 2H₂O

• Molecular Weight:

  510.5

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Gerlach A.C., Stoehr S.J., Castle N.A. (2010) Mol Pharmacol. 77(1): 56-68. 2. Perrin M.J., et al. (2008) Prog Biophys Mol Biol. 98: 137-148. 3. Sanguinetti M.C., Jurkiewicz N.K. (1990) J Gen Physiol. 96: 195-215. 4. Spector P.S., Curran M.E., Keating M.T., and Sanguinetti M.C. (1996) Circ Res. 78: 499-503. 5. Miyake K., et al. (1990) J Med Chem. 33: 903.

• CAS Number:

  113558-89-7