2-APB

• Background:

  2-APB is a chemical that acts to inhibit IP3 receptors (1) and TRP channels (2). It is used to manipulate intracellular release of calcium ions and modify TRP channel activity. There is also evidence that 2-APB acts directly to inhibit gap junctions made of connexin26 or connexin32 (3).

• Description:

  TRP blocker

• Product Name Alternative:

  2-Aminoethoxydiphenylborane

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Neuroscience | Ion Channels | Transient Receptor Potential (TRP) Channels

• Purity:

  >98%

• Weight:

  0.05

• Format:

  White solid

• Solubility:

  Soluble to 100 mM in DMSO and to 10 mM in ethanol

• Molecular Formula:

  C14H16BNO

• Molecular Weight:

  225.1

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Diver J.M., Sage S.O., Rosado J.A. (2001) Cell Calcium. 30(5): 323-329 2. Xu S.Z., et al. (2005) Br J Pharamcol. 145(4): 320-328. 3. Tao L., and Harris A.L. (2007) Mol Pharmacol. 71(2): 570-579.

• CAS Number:

  524-95-8