Dofetilide

• Background:

  Dofetilide is a class III antiarrhythnic agent (1). It works by selectively blocking the rapid component of the delayed rectifier outward potassium current (2).

• Description:

  Herg channel blocker

• Product Name Alternative:

  N- (4-{2-[Methyl (2-{4-[ (methylsulfonyl) amino]phenoxy}ethyl) amino]ethyl}phenyl) methanesulfonamide, Tikosyn, UK 68798

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Neuroscience | Ion Channels

• Purity:

  >98%

• Weight:

  0.05

• Format:

  White Solid

• Solubility:

  Soluble to 100 mM in DMSO

• Molecular Formula:

  C19H27N3O5S2

• Molecular Weight:

  441.56

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Lentz T.L., Hilleman D.E. (2000) Pharmacotherapy. 20(7): 776-786. 2. Roukoz H., Saliba W. (2007) Expert Rev Cardiovasc Ther. 5(1): 9-19.

• CAS Number:

  115256-11-6