HC-030031

• Background:

  Selective TRPA1 channel blocker that antagonizes AITC-and formalin-evoked calcium influx. Doe not block currents mediated by TRPV1, V3, V4, hERG or Nav1.2 channels (1-2).

• Description:

  TRPA1 blocker

• Product Name Alternative:

  2- (1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl) -N- (4-isopropylphenyl) acetamide

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Neuroscience | Ion Channels | Transient Receptor Potential (TRP) Channels

• Purity:

  >98%

• Weight:

  0.05

• Format:

  White solid

• Solubility:

  Soluble to 100 mM in DMSO

• Molecular Formula:

  C18H21N5O3

• Molecular Weight:

  355.39

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. McNamara C.R., et al. (2007) Proc Natl Acad Sci USA. 104(33): 13525-13530. 2. Taylor-Clark T.E., et al. (2008) Mol Pharmacol. 73(2): 274-281.

• CAS Number:

  349085-38-7