Astemizole

• Background :

  Astemizole is a second generation antihistamine drug which has a long duration of action. It binds to histamine H1-receptor sites in the gastrointestinal tract, uterus, blood vessels and bronchial muscle. It does not cross the blood-brain barrier, and the binding is primarily in the peripheral nervous system (1). It is metabolized by CYP3A4 (2).

• Description :

  Herg channel blocker

• Product Name Alternative :

  1- (4-Fluorobenzyl) -N-{1-[2- (4-methoxyphenyl) ethyl]-4-piperidinyl}-1H-benzimidazol-2-amine, Hismanal

• UNSPSC :

  41116105

• Type :

  Inhibitor

• Source :

  Synthetic

• Field of Research :

  Neuroscience | Ion Channels

• Purity :

  >98%

• Weight :

  0.05

• Format :

  White solid

• Solubility :

  Soluble to 100 mM in DMSO and to 25 mM in ethanol

• Molecular Formula :

  C28H31FN4O

• Molecular Weight :

  458.57

• Precautions :

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations :

  1. Laduron P.M., Janssen P.F., Commeren W. and Leysen J.E. (1982) Mol Pharmacol. 21(2): 294-300. 2. Maysumoto S., Yamazoe Y. (2001) Br. J Clin Pharamcol. 51(2): 133-142.

• CAS Number :

  68844-77-9