Troglitazone

• Background :

  Troglitazone, a member of the thaizolidinediones, is an anti-diabetic and anti-inflammatory drug. It works by activating peroxisome proliferator-activated receptors (PPARs) (1). It is a ligand to both PPARalpha and gamma. It also contains an alpha-tocopheroyl moiety, potentially giving it vitamin E like activity (which helps in inflammation) (2).

• Description :

  PPARgamma agonist

• Product Name Alternative :

  5-{4-[ (6-Hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromen-2-yl) methoxy]benzyl}-1,3-thiazolidine-2,4-dione, Rezulin

• UNSPSC :

  41116105

• Type :

  Agonist

• Source :

  Synthetic

• Field of Research :

  Cancer | Apoptosis

• Purity :

  >98%

• Weight :

  0.01

• Format :

  White solid

• Solubility :

  Soluble to 100 mM in DMSO and to 10 mM in ethanol

• Molecular Formula :

  C24H27NO5S

• Molecular Weight :

  441.54

• Precautions :

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations :

  1. Lambe K.G. and Tugwood J.D. (1996) Eur J Biochem. 239(1): 1-7. 2. Aljada A., et al. (2001) J Clin Endocrinol Metab. 86(7): 3250-3256.

• CAS Number :

  97322-87-7