Dexamethasone

• Background:

  Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs. It is an anti-inflammatory and immunosuppressant. In cancer patients, it can be give to augment the antiemetic effect of 5-HT3 receptor antagonists, and is also used to counteract the development of edema (1). In a diagnostic setting, it is used to suppress the natural pituitary-adrenal axis (2).

• Description:

  Glucocorticoid receptor ligand

• Product Name Alternative:

  (11β,16α) -9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione

• UNSPSC:

  41116105

• Type:

  Inducer

• Source:

  Synthetic

• Field of Research:

  Cancer | Apoptosis

• Purity:

  >98%

• Weight:

  5

• Format:

  White solid

• Solubility:

  Soluble to 100 mM in DMSO

• Molecular Formula:

  C22H29FO5

• Molecular Weight:

  392.47

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Roila F., and Fatigoni S. (2006) Ann Oncol.17 (Suppl2): ii96-ii100. 2. Hasan E.A., Jessop D.S., Power L.L. Monk P.T. and Kirwan J.R. (2009) Int J Endocrinol. 2009: 391284.

• CAS Number:

  50-02-2