Trichostatin A

• Background:

  Trichostatin A is an antifungal and selectively inhibits the class I and II mammalian histon deacetlyase families of enzymes (1). TSA inhibits the eukayotic cell cycle during the beginning of the growth stage. It can be used to alter gene expression but interfering with the removal of acetyl groups thereby altering the ability of DNA transcription factors to access the DNA inside chromatin (2). It also has anti-cancer properties (3).

• Description:

  HDAC inhibitor

• Product Name Alternative:

  (2E,4E,6R) -7-[4- (Dimethylamino) phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cancer | Apoptosis | Cancer Growth Inhibitors | HDAC Inhibitors

• Purity:

  >98%

• Weight:

  0.001

• Format:

  Beige Solid

• Solubility:

  Soluble to 10 mM in ethanol and to 50 mM in DMSO

• Molecular Formula:

  C17H22N2O3

• Molecular Weight:

  302.37

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Vanhaecke T., Papeleu P., Elaut G., Rogiers V. (2004) Curr Med Chem. 11(12): 1629-1643. 2. Yoshida, et al. (1990) J Biol Chem. 165: 17174. 3. Drummond D.C., et al. (2005) Annu Rev Pharmacol Toxicol. 45: 495-528.

• CAS Number:

  58880-19-6