Apigenin

• Background:

  Apigenin induces a process called autophagia (1). It is a potent inhibitor of CYP2C9, an enzyme responsible for the metabolism of many pharmaceutical drugs in the body (2). Apigenin has also been shown to reverse the adverse effects of cyclosporine (3).

• Description:

  Protein kinase inhibitor

• Product Name Alternative:

  5,7-Dihydroxy-2- (4-hydroxyphenyl) -4H-chromen-4-one

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors

• Purity:

  >98%

• Weight:

  0.05

• Format:

  White Solid

• Solubility:

  Soluble to 50 mM in DMSO

• Molecular Formula:

  C15H10O5

• Molecular Weight:

  270.2

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Ruela-de-Sousa R.R., et al. (2010) Cell Death and Disease. 1(e19): 1-11. 2. Dayong S.I., et al. (2009) Drug Metabolism and Disposition. 37(3): 629-634. 3. Chakravarthi S., Wen C.F., Nagaraja H.S. (2009) J Anal Bio Sci. 32(4): 320-327.

• CAS Number:

  520-36-5