Camptothecin

• Background:

  Camptothecin is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme topoisomerase I. It binds to the topo I and DNA complex, resulting in a tertiary comlex which stabilizes it. This prevents re-ligation and therefore causes DNA damage which results in apoptosis (1-3). It has showed remarkable anti-cancer activity in clinical trials.

• Description:

  Topoisomerase I inhibitor

• Product Name Alternative:

  (4S) -4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14 (4H,12H) -dione

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cancer | Apoptosis

• Purity:

  >98%

• Weight:

  1

• Format:

  Yellow solid

• Solubility:

  Soluble to 5 mM in DMSO

• Molecular Formula:

  C20H16N2O4

• Molecular Weight:

  348.36

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Adams D.J., et al. (2005) Cancer Chem and Pharm. 57(2): 145-154. 2. Redinbo M.R., Stewart L., Kuhn P., Champoux J.J. and Hol W.G.J. (1998) Science. 279:1504-1513. 3. Pommier Y., et al. (2003) Mutat Res. 532: 173-203.

• CAS Number:

  7689-03-4