Camptothecin
CAT:
400-SIH-242-100MG
Size:
100 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Camptothecin
- Background: Camptothecin is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme topoisomerase I. It binds to the topo I and DNA complex, resulting in a tertiary comlex which stabilizes it. This prevents re-ligation and therefore causes DNA damage which results in apoptosis (1-3). It has showed remarkable anti-cancer activity in clinical trials.
- Description: Topoisomerase I inhibitor
- Product Name Alternative: (4S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- CAS Number: 7689-03-4
- UNSPSC: 41116105
- Source: Synthetic
- Purity: >98%
- Weight: 0.1
- Format: Yellow solid
- Solubility: Soluble to 5 mM in DMSO
- Molecular Formula: C20H16N2O4
- Molecular Weight: 348.36
- Precautions: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
- References & Citations: 1. Adams D.J., et al. (2005) Cancer Chem and Pharm. 57(2): 145-154. 2. Redinbo M.R., Stewart L., Kuhn P., Champoux J.J. and Hol W.G.J. (1998) Science. 279:1504-1513. 3. Pommier Y., et al. (2003) Mutat Res. 532: 173-203.