Docetaxel

• Background:

  Docetaxel is a semi-synthetic analogue of paclitaxel differing at two positions in its chemical structure (1). It also binds and stabilizes microtubules which leads to cell cycle arrest and apoptosis (2).

• Description:

  Microtubule stabilizer

• Product Name Alternative:

  (2α,5β,7β,10β,13α) -4-Acetoxy-1,7,10-trihydroxy-13-{[ (2R,3S) -2-hydroxy-3- ({[ (2-methyl-2-propanyl) oxy]carbonyl}amino) -3-phenylpropanoyl]oxy}-9-oxo-5,20-epoxytax-11-en-2-yl benzoate

• UNSPSC:

  41116105

• Type:

  Inducer

• Source:

  Synthetic

• Field of Research:

  Cancer | Apoptosis

• Purity:

  >98%

• Weight:

  0.05

• Format:

  White solid

• Solubility:

  Soluble to 100 mM in DMSO, and to 100 mM in ethanol

• Molecular Formula:

  C43H53NO14

• Molecular Weight:

  807.88

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Clarke S.J., and Rivory L.P. (1999) Clin Pharmacokinet. 36(2): 99-114. 2. Woodward E.J. and Twelves C. (2010) Curr. Clin Pharmacol. 5(3): 226-231.

• CAS Number:

  114977-28-5