Fumonisin B1

• Background :

  Fumonisin B1 is the most prevalent member of a family of toxins. It is hepatotoxic and nephrotoxic in all animal species. It occupies the space and electrostatic interactions of both sphinganine and fatty acyl-CoA (1). Due to this mechanism of action, it has toxic effects in humans such as neural tube defects (2), esophageal cancer, acute mycotoxicosis, and various other carcinogenic effects. Another effect of exposure to FB1 is apoptosis (2).

• Description :

  Ceramide synthase inhibitor

• CAS Number :

  116355-83-0

• Product Name Alternative :

  2,2'-{ (19-Amino-11,16,18-trihydroxy-5,9-dimethyl-6,7-icosanediyl) bis[oxy (2-oxo-2,1-ethanediyl) ]}disuccinic acid

• UNSPSC :

  41116105

• Type :

  Inducer

• Source :

  Synthetic

• Field of Research :

  Cancer | Apoptosis

• Purity :

  >98%

• Weight :

  0.005

• Format :

  Beige Solid

• Solubility :

  Soluble to 10 mM in DMSO

• Molecular Formula :

  C34H59NO15

• Molecular Weight :

  721.83

• Precautions :

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations :

  1. European commission (2007). “Fumonisin B1”. Opinion of the scientific committee on food on Fusarium toxins (27). 2. Stockmann-Juvalla H., and Savolainen K. (2008) Human and Exp. Toxicology. 27: 799-809.