Nigericin

• Background:

  Nigericin acts as a K and Na ionophore. It stimulates Ca release from mitochondrial stores by disruption of membrane potential.

• Description:

  NALP3 activator

• Product Name Alternative:

  (2R) -2-[ (2R,3S,6R) -6-{[ (2S,4R,5R,7R,9R,10R) -2-{ (2S,2'R,3'S,5R,5'R) -5'-[ (2S,3S,5R,6R) -6-Hydroxy-6- (hydroxymethyl) -3,5-dimethyltetrahydro-2H-pyran-2-yl]-2,3'-dimethyloctahydro-2,2'-bifuran-5-yl}-9-metho xy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]dec-7-yl]methyl}-3-methyltetrahydro-2H-pyran-2-yl]propanoic acid

• UNSPSC:

  41116105

• Type:

  Inducer

• Source:

  Synthetic

• Field of Research:

  Cancer | Apoptosis

• Purity:

  >98%

• Weight:

  0.01

• Format:

  White to off-white Solid

• Solubility:

  Soluble to 50 mM in DMSO and 20 mM in ethanol

• Molecular Formula:

  C40H67NaO11

• Molecular Weight:

  746.94

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Vercesi A.E., et al. (1993) J Biol Chem. 268: 8564. 2. Graven S.N., Estrada-O, S., Lardy H.A. (1966) Proc Natl Acad Sci USA. 56(2): 654-658.

• CAS Number:

  28643-80-3