Ionomycin

• Background:

  Ionomycin is a calcium ionophore used in research to raise the intracellular level of calcium and as a tool to understand calcium transport across biological membranes. It is also used to stimulare the intracellular production of the cytokines interferon, perforin, IL-2 and IL-4. It is more specific than A23187.

• Description:

  Ca2+ ionophore

• Product Name Alternative:

  (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S) -11,19,21-Trihydroxy-22-{ (2S,2'R,5S,5'S) -5'-[ (1R) -1-hydroxyethyl]-2,5'-dimethyloctahydro-2,2'-bifuran-5-yl}-4,6,8,12,14,18,20-heptamethyl-9-oxo-10,16-docosadi enoic acid, Ionomycin calcium salt

• UNSPSC:

  41116105

• Type:

  Inducer

• Source:

  Synthetic

• Field of Research:

  Cancer | Apoptosis

• Purity:

  >98%

• Weight:

  0.005

• Format:

  Colorless Solid

• Solubility:

  Soluble to 10 mM in ethanol and to 10 mM in DMSO

• Molecular Formula:

  C41H70O9

• Molecular Weight:

  709.01

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Holmes A.G. Watt M.J., Carey A.L. And Febbraio M.A. (2004) Metabolism. 53(11): 1492-1495. 2. Abramov A.Y., Duchen M.R. (2003) Cell Calcium. 33(2): 101-112.

• CAS Number:

  56092-81-0