Brefeldin A

• Background:

  Brefeldin A is a reversible inhibitor of proteins from the endoplasmic reticulum (ER) to the golgi. In mammalian and yeast cells, Brefeldin A targets certain GTP-exchange factosr responsible for activating a GTPase called Arf1p (1, 2).

• Description:

  GEF inhibitor

• Product Name Alternative:

  Cyanaein

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cancer | Apoptosis

• Purity:

  >98%

• Weight:

  0.005

• Format:

  White Crystalline Solid

• Solubility:

  Soluble to 10 mM in ethanol and to 50 mM in DMSO

• Molecular Formula:

  C16H24O4

• Molecular Weight:

  280.36

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Klausner R.D., Donaldson J.G., Lippincott-Schwartz J. (1992) J Cell Biol. 116(5): 1071-1080. 2. Nebenfuhr A., Ritzenthaler C., and Robinson D.G. (2002) Plant Physiol. 130(3): 1102-1108.

• CAS Number:

  20350-15-6