PK-11195

• Background:

  PK-11195 is an isoquinoline carboxamide which binds selectively to the peripheral benzodiazepine receptor (PBR). It has a high affinity for the PBR in all species (1). It has also been successfully used in PET scans to visualize brain inflammation in patients with neuronal damage (2).

• Description:

  Mitochondrial Benzodiazepine receptor ligand

• Product Name Alternative:

  N-sec-Butyl-1- (2-chlorophenyl) -N-methyl-3-isoquinolinecarboxamide

• UNSPSC:

  41116105

• Type:

  Inducer

• Source:

  Synthetic

• Field of Research:

  Cancer | Apoptosis

• Purity:

  >98%

• Weight:

  0.025

• Format:

  White Crystals

• Solubility:

  Soluble to 75 mM in ethanol and to 100 mM in DMSO

• Molecular Formula:

  C21H21CIN2O

• Molecular Weight:

  352.86

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Pike V.W., et al. (1993) Nucl Med & Bio. 20(4): 503-525. 2. Buck J.R., et al. (2011) J Nucl Med. 52(1): 107-114.

• CAS Number:

  85532-75-8