R (-) -Gossypol

• Background :

  Gossypol is a natural phenol derived from the cotton plant, and is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. It has proapoptotic properties, due to the regulation of the Bax and Bcl2. It also reversibly inhibits calcineurin and binds to calmodulin (1, 2).

• Description :

  Bcl-2 inhibitor

• Product Name Alternative :

  1,1',6,6',7,7'-Hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-2,2'-binaphthalene-8,8'-dicarbaldehyde, Gossypol

• UNSPSC :

  41116105

• Type :

  Inducer

• Source :

  Synthetic

• Field of Research :

  Cancer | Apoptosis

• Purity :

  >98%

• Weight :

  0.01

• Format :

  Dark Yellow Solid

• Solubility :

  Soluble to 25 mM in ethanol and in DMSO.

• Molecular Formula :

  C30H30O8

• Molecular Weight :

  518.56

• Precautions :

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations :

  1. www.bioscreening.net “Gossypol” 2. Carruthers N.J., Dowd M.K., and Stemmer P.M. (2007) Eur J Pharmacol. 555(2-3): 106-114.

• CAS Number :

  303-45-7