FK506

• Background:

  FK506 or Fujimycin or Tacrolimus, is an immunosuppressant. It is mainly used after allogeneic organ transplants, but can also be used topically in the treatment of eczema, uveitis and vitiligo (1). It is a macrolide that prevents the dephosphorylation of NF-AT. It reduces peptidyl-prolyl isomerase activity by binding to FKBP12 creating a new complex that interacts with and inhibits calcineurin (2, 3). It is a neuroprotective in a model of antiretroviral toxic neuropathy (4).

• Description:

  FKBP inhibitor

• Product Name Alternative:

  3- (3-Pyridinyl) propyl 1- (3,3-dimethyl-2-oxopentanoyl) prolinate, Tacrolimus, Fujimycin

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cancer | Apoptosis | Neuroscience | Cell Death | Necroptosis

• Purity:

  >98%

• Weight:

  0.01

• Format:

  White powder

• Solubility:

  May be dissolved in DMSO (50 mg/mL) or ethanol (50mg/mL)

• Molecular Formula:

  C44H69HO12

• Molecular Weight:

  804

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Nanette B., et al. (2004) J Am Acad Derm. 51(5): 760-766. 2. Ganong W.F., Review of Medical Physiology (22nd ed.) Lange Medical Books. P.530 3. Liu J. Lane W., Friedman J, Weissman I and Schreiber S. (1991) Cell. 66(4): 807-815 4. Keswani S., et al. (2003) Ann Neurol. 53(1): 57-64.

• CAS Number:

  104987-11-3