Necrostatin

• Background:

  Necrostatin-1 is a specific inhibitor of necroptosis that reduces ischemic tissue damage in stroke models (1). It has also been recently confirmed to be an allosteric RIP1 kinase inhibitor, preotective in NMDa-mediated excitotoxicity and acute pathologies (2,3).

• Description:

  Necroptosis inhibitor

• Product Name Alternative:

  5- (1H-Indol-3-ylmethyl) -3-methyl-2-thioxo-4-imidazolidinone, Necrostatin-1

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cancer | Apoptosis

• Purity:

  >98%

• Weight:

  0.05

• Format:

  Light Yellow Solid

• Solubility:

  Soluble to 15 mM in ethanol, and to 30 mM in DMSO

• Molecular Formula:

  C13H13N3OS

• Molecular Weight:

  259.33

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. You Z., et al. (2008) J Cereb Blood Flow Metab. 28(9): 1564-1573. 2. Vandenabeele P., et al. (2010) Nat Rev Mol Cell Biol. 11:700-714. 3. Degterev A., et al. (2008) Nat Chem Biol. 4: 313-321.

• CAS Number:

  4311-88-0