Rapamycin

• Background:

  Rapamycin or Sirolimus is an immunosuppressant and antifungal. It inhibits the response to interleukin-2, and therefore blocks activation of T and B cells. It binds FKBP12 which then inhibits the mTOR pathway (1). There is also potential treatment for Alzheimer;s, autism and HIV infection (2-3).

• Description:

  MTOR inhibitor

• Product Name Alternative:

  (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R) -1,18-Dihydroxy-12-{1-[ (1S,3R,4R) -4-hydroxy-3-methoxycyclohexyl]-2-propanyl}-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatr icyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene2,3,10,14,20-pentone

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cancer | Apoptosis | Cancer Growth Inhibitors | mTOR Inhibitors | Neuroscience | Neurodegeneration | Alzheimer's Disease

• Purity:

  >98%

• Weight:

  0.005

• Format:

  White Solid

• Solubility:

  Soluble to 100 mM in ethanol, and to 50 mM in DMSO

• Molecular Formula:

  C51H79NO13

• Molecular Weight:

  914.18

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Gruppuso P.A., Boylan J.M., and Sanders J.A. (2011) Cell Cycle. 10(7): EPub. 2. Ehninger D., et al. (2008) Nat. Med. 14(8): 843-848. 3. Donia M., McCubrey J.A., Bendtzen K., and Nicoletti F. (2010) Br J Clin Pharmacol. 70(6): 784-793.

• CAS Number:

  53123-88-9