Forskolin

• Background:

  Forskolin resensitizes cell receptors by activating adenyl cyclase, and increasing the intracellular levels of cAMP (1). Medically forskolin provides a route to inhibition of colon cancer cell growth and survival (2). It is also a vasodilator, may be helpful in controlling the cause of glaucoma (3), reduces urinary tract infections, and may help to increase the skin's natural resistance to burning under UV light (1).

• Description:

  Adenylate cyclase activator

• Product Name Alternative:

  (3R,4aR,5S,6S,6aS,10S,10aR,10bS) -6,10,10b-Trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyldodecahydro-1H-benzo[f]chromen-5-yl acetate

• UNSPSC:

  41116105

• Type:

  Activator

• Source:

  Synthetic

• Field of Research:

  Cancer | Apoptosis

• Purity:

  >99%

• Weight:

  0.01

• Format:

  White Solid

• Solubility:

  Soluble to 100 mM in DMSO, and to 10 mM in ethanol

• Molecular Formula:

  C22H34O7

• Molecular Weight:

  410.51

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Passeron T., Namiki T., Passeron H.J., Le Pape E., and Hearing V.J. (2009) J Invest Dermatol. 129(1): 162-166. 2. McEwan D.G., Brunton V.G., Baillie G.S., Leslie N.R., Houslay M.D., and Frame M.C. (2007) Cancer Research. 67(11). 3. Pescosolido N., and Librando A. (2010) Clin Ter. 161(3): e81-5.

• CAS Number:

  66575-29-9