Sphingosine

• Background:

  Sphingosine can be phosphorylated in vivo via two kinases which leads to the formation of a potent signaling lipid. It is a selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. It also inhibits calmodulin-dependent enzymes and is the precursor of ceramide.

• Description:

  Protein Kinase C inhibitor

• Product Name Alternative:

  (2S,3R,4E) -2-Amino-4-octadecene-1,3-diol

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors

• Purity:

  >98%

• Weight:

  0.025

• Format:

  Solid

• Solubility:

  Soluble to 100 mM in DMSO

• Molecular Formula:

  C18H37NO2

• Molecular Weight:

  299.49

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Radin N. (2003) Biochem J. 371(Pt2): 243-256. 2. Carter H.E., Glick F.J., Norris W.P., Phillips G.E. (1947) J Biol Chem. 170: 285-295.

• CAS Number:

  123-78-4