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Cyclosporine

CAT: 0400-SIH-201-25MGSize: 25 mgDry Ice: NoHazardous: No
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CAT#:0400-SIH-201-25MGSize:25 mg
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Background
Cyclosporin A is a hydrophobic cyclic peptide, and is a potent immune-suppressant and antifungal. It acts via its ability to bind to a family of intracellular proteins (1). The immunosuppressant action is mediated by the complex Cyclosporin-A-cyclophilin that specifically inhibits the Ca2+/calmodulin-dependent serine-threonine-protein phosphatase-2B. This is turn inhibits calcineurin and promotes dephosphorylation of transcription factor NF-AT and T-cell activation (2).
Description
Immunosuppressant
CAS Number
59865-13-3
Product Name Alternative
(3S,6S,9S,12R,15S,18S,21S,24S,30S,33S) -30-Ethyl-33-[ (1R,2R,4E) -1-hydroxy-2-methyl-4-hexen-1-yl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,3 1-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone, Cyclosporin A
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Apoptosis
Purity
>99%
Weight
0.025
Format
White Solid
Solubility
Soluble to 100 mM in DMSO, 50 mM in ethanol
Molecular Formula
C62H111N11O12
Molecular Weight
1202.63
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Heitman J., et al. (1992) New Biol. 4:448. 2. Ganong W.F. Review of Medical Physiology, 22nd edition. Lange Medical Books, Chapter 27, Page 530.

Alternative Products

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B8309-50Cyclosporine
1522-1GCyclosporine A
RP-1552Cyclosporine-A

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